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15(5):783-93
Schultes CM
GW-9662 is a potent and selective antagonist of full-length PPARγ
Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates
with good results
NVP-BSK805 Size:2mg solid 15(5):783-93NVP BSK805 is a JAK2 inhibor, which displays more than 20 fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. In vivo, NVP BSK805 exhibited good oral bioavailability and a long half life. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba F3 JAK2(V617F) cell driven mouse mechanistic model. Furthermore, NVP BSK805 potently suppressed recombinant human
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