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Epub 2014 Apr 23
TLX agonist 1 potentiates TLX transcriptional repressive activity
Formula: C21H20N2O3S
CAS Number: 84176-65-8
Epub 2015 Sep 16
K145 - CAS# 1309444-75-4 Size:Solid 2 mg Epub 2014 Apr 23K145 is a selective sphingosine kinase 2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose dependent manner with an IC50 of 4. 300. 06 M. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. Product
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