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it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse
transcription factor activity is measured
Smiles: [O-]N1C2=CC=CC=C2[N+](=O)C(CBr)=C1CBr
InChi: InChI=1S/C35H49N3O4/c1-21(2)10-9-11-22(3)28-14-15-29-27-20-31(26-18-25(39)19-32(40)23(26)4)38-34(42)36(24-12-7-6-8-13-24)33(41)37(38)30(27)16-17-35(28
Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1
A-437203 Catalog No.:M18760-C it reduces aortic collagen depositionsA 437203 is a selective D3 receptor antagonist with Ki of 71, 1. 6, and 6220 nM for D2, D3, and D4 receptors, respectively. Product information CAS Number: 220519 06 2 Molecular Weight: 456. 53 Formula: C20H27F3N6OS Chemical Name: 2 [(3 {4 [2 tert butyl 6 (trifluoromethyl)pyrimidin 4 yl]piperazin 1 yl}propyl)sulfanyl] 3,4 dihydropyrimidin 4 one Smiles: CC(C)(C)C1N=C(C=C(N=1)C(F)(F)F)N1CCN(CCCSC2NC(=O)C=CN=2)CC1 InChiKey: KXVAICSRMHXLJN UHFFFAOYSA N