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Climbazole is a potent inhibitor of exosome biogenesis and/or secretion
11(4):497-505
Ficarro SB
InChi: InChI=1S/C18H18FN3OS/c1-2-21(14-8-6-12(19)7-9-14)11-13-10-17(23)22-15-4-3-5-16(15)24-18(22)20-13/h6-10H
5-dihydro-6-[(3S
ARM1 entiobiosiden Climbazole is a potent inhibitorARM1 (4 (4 benzylphenyl) thiazol 2 amine) is a LTB4 synthesis inhibitor . Leukotriene A4 (LTA4) hydrolase aminopeptidase is a bifunctional zinc metalloenzyme that catalyzes the synthesis of the proinflammatory mediator LTB4 from LTA4 and cleaves the chemotactic tripeptide Pro Gly Pro. LTB4 is a key lipid mediator in the innate immune response . ARM1 is a LTB4 synthesis inhibitor. ARM1 is a thiazolamine that inhibits LTB4 synthesis and conversion of
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