BAY 61-3606 dihydrochloride ntel and induces apoptosis likely by

and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM)

Z1124160693

Chemical Name: N'-(5-chloropyridin-2-yl)-N-[(1S

PubMed Central PMCID: PMC5589819

InChi: InChI=1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H

BAY 61-3606 dihydrochloride ntel and induces apoptosis likely byBAY 61 3606 is a potent (Ki = 7. 5 nM) and selective inhibitor of Syk kinase. BAY 61 3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61 3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8. 1 nM). B cell receptor