W-54011 Catalog No.:M20237-C Smiles: CN1CCN(CC2C=CC(=CC=2)C(=O)NC2=CC(NC3=NC(=CS3)C3=CN=CC=C3)=C(C)C=C2)CC1

Smiles: CN1CCN(CC2C=CC(=CC=2)C(=O)NC2=CC(NC3=NC(=CS3)C3=CN=CC=C3)=C(C)C=C2)CC1

indicating that NHC-TP competes predominantly with CTP for incorporation

2ClH/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20

87(1):83-7

Formula: C26H21F2N5O3

W-54011 Catalog No.:M20237-C Smiles: CN1CCN(CC2C=CC(=CC=2)C(=O)NC2=CC(NC3=NC(=CS3)C3=CN=CC=C3)=C(C)C=C2)CC1W 54011 is a potent and orally active non peptide C5a receptor antagonist. W 54011 inhibits the binding of 125I labeled C5a to human neutrophils with a Ki value of 2. 2 nM. W 54011 also inhibits C5a induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3. 1 nM, 2. 7 nM, and 1. 6 nM, respectively. Product information CAS Number: 405098 33 1 Molecular Weight: 493. 08 Formula: C30H37ClN2O2 Chemical