CHIR-090 - CAS# 728865-23-4 0027 08 µM) and has shown

08 µM) and has shown dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers

CNV-1014802

35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

PubMed PMID: 22736948

New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide

CHIR-090 - CAS# 728865-23-4 0027 08 µM) and has shownCHIR 090, CAS No. 728865 23 4, is a very potent and selective LpxC inhibitor. CHIR 090 has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli. CHIR 090 is also a two step slow, tight binding inhibitor of E. coli LpxC with Ki = 4. 0 nM, Ki* = 0. 5 nM, k5 = 1. 9 min 1, and k6 = 0. 18 min 1. CHIR 090 at low nanomolar levels inhibits LpxC orthologues from diverse Gram negative pathogens, including P. aeruginosa, Neisseria