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InChiKey: YJGVMLPVUAXIQN-LGWHJFRWSA-N
CAS Number: 1356962-34-9
7 μM in human breast MCF-7 cells in culture
This Alantolactone-induced apoptosis is found to be associated with GSH depletion
CAS Number: 1069-66-5
(Z)-Mirin Size:Contact [email protected] for quotation InChiKey: YJGVMLPVUAXIQN-LGWHJFRWSA-NMirin is a small molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Target: in vitro: Mirin was shown to block Mre11 exonuclease activity and MRN dependent ATM activation, and to inhibit the ionizing radiation induced G2 M checkpoint and homologous recombination in mammalian cells. Mirin inhibition of ATM activation is independent of Mre11 nuclease inhibition since the M(HN)RN and M(HL DV)RN mutant complexes are inhibited equivalently to the
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