Exploring Magic 2015 Even more than any core set in the past, there's plenty of new and crazy stuff to do and explore in Magic 2015
In all seriousness, this is probably only worthwhile for strategies with a truly obnoxiously expensive Commander, and in any 60-card format I just don't see it
You can use it against greedy self-mill decks that are looking to reanimate a bunch of creatures and its even efficient enough to see play in higher power tables where cards such as Underworld Breach are mainstays
On a smaller scale, Minas Tirith Garrison and Syr Elenora, the Discerning both add to your hand and get powered up from it
An Azorius lawmage learns the true value of the law
Even a card like Greater Good can be turned into a self-mill piece so long you have enough creatures to sacrifice and cards to discard, though it might not have been on your radar in regards to self-milling before