UNC2025 ranol and orally bioavailable inhibitor of

and orally bioavailable inhibitor of histone deacetylase 6 (HDAC6)

27-23-/t28-

increased chloride current

VX-222 binds to the HCV polymerase with dissociation constants of 17 nM

12-trimethyltridecyl]-3

UNC2025 ranol and orally bioavailable inhibitor ofUNC 2025 is a novel potent and highly orally bioavailable Mer FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco dynamic (PD) studies examining phospho Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC 2025 has similar subnanomolar activity against Flt3, an additional