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or IP dosed at 25 mg/kg once a day on a 5-on
Erk1/2- and Stat3 activity in both cell lines
In recent publication CI994 could also epigenetically prime the hippocampal transcriptome for reinstated neuroplasticity and lead to increased neuroplasticity during memory extinction
Molecular Weight: 524
independently of PHD
AG-120 (Ivosidenib) - IDH1 Inhibitor. CAS# 1448347-49-6 Catalog No.:M60318-10S or IP dosed at 25AG 120 (Ivosidenib), CAS No. 1448347 49 6, is a potent, selective and reversible inhibitor of IDH1 with IC50 < 100 nM. It has been shown to lower 2 HG levels and restore cellular differentiation in IDH1 mutant primary human blast cells cultured ex vivo. In phase I clinical trials targeting patients with IDH1 mutated, relapsed and or refractory (R R) AML or untreated AML not eligible for standard of care or R R MDS, AG 120 is well tolerated to date (10
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