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depletion of BRD2 and BRD4 with dBET1 is associated with dramatically reduced LPS-induced COX-2 and iNOS protein levels and pro-inflammatory gene transcription of Nos2
It selectively inhibits low–molecular mass polypeptide-7 (LMP7
MLN-9708 induces cleavage of caspase-3
Guzeloglu A
(43):5438-40
MZ 1 A (TSA) depletion of BRD2 and BRD4MZ1 is a potent inducer of reversible, long lasting and selective removal of BRD4 over BRD2 and BRD3. Product information CAS Number: 1797406 69 9 Molecular Weight: 1002. 64 Formula: C49H60ClN9O8S2 Chemical Name: (4R) N [14 [(6S) 4 (4 chlorophenyl) 2, 3, 9 trimethyl 6H thieno[3, 2 f][1, 2, 4]triazolo[4, 3 a][1, 4]diazepin 6 yl] 1, 13 dioxo 3, 6, 9 trioxa 12 azatetradec 1 yl] 3 methyl L valyl 4 hydroxy N [[4 (4 methyl 5 thiazolyl)phenyl]methyl] L
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