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GI50 values for all cell lines tested are similar (40-84 nM)
11)26/h6-11
28(20):3356-3362
Formula: C22H16F3N3O2S
CAS Number: 2070009-72-0
Semapimod tetrahydrochloride (disodium salt) GI50 values for all cellSemapimod tetrahydrochloride (CNI 1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF , IL 1, and IL 6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC500. 3 M). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders. Product information CAS Number: 164301 51 3 Molecular Weight: 890. 74
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