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In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244
colorectal and lung cancer cells that exhibited low nM EC50 and rapid induction of apoptosis
a constituent of Indian Ayurvedic medicinal plant Commiphora mukul
InChiKey: GJPXGFGIFQWUOC-ACFHMISVSA-N
CHMFL-EGFR-202 also exhibits strong binding affinities against BLK
ML346 27802 In vitro cell viability inhibitionML346 is an activator of Hsp70 expression and HSF 1 activity, with an EC50 of 4. 6 M for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27. Product information CAS Number: 100872 83 1 Molecular Weight: 272. 26 Formula:
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