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Smiles: CC1CN(CCN1)C1=C(F)C=C2C(=C1OC)N(C=C(C2=O)C(O)=O)C1CC1
MEISi-2 down-regulates MEIS target gene expression
Chemical Name: 4-hydroxy-N-[(5E
Epub 2019 Aug 9
CAS Number: 1417329-24-8
RapaLink-1 ide hemihydrate Smiles: CC1CN(CCN1)C1=C(F)C=C2C(=C1OC)N(C=C(C2=O)C(O)=O)C1CC1RapaLink 1, the third generation bivalent mTOR inhibitor, combines Rapamycin (HY 10219) with MLN0128 (HY 13328, a second generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink 1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer derived, activating mutants of mTOR. RapaLink 1 can cross the blood brain barrier. RapaLink 1 binding to FKBP12 results in targeted and durable inhibition of
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