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Smiles: N#CC(CC1=CC=C(O)C=C1)C1C=CC(O)=CC=1
Nutlin-3 treatment at 10 μM for 48 hours significantly induces caspase-dependent cell apoptosis by ~45%
CAS Number: 1049741-55-0
Pre-clinically LY-2090314 i stabilizes β-catenin and enhances the efficacy of platinum based regimens
Formula: C17H16BrF3N4O
AZD-7762 - CAS# 860352-01-8 Catalog No.:M10890-2 Smiles: N#CC(CC1=CC=C(O)C=C1)C1C=CC(O)=CC=1AZD 7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA damaging agents. Chks are protein kinases that regulate either G1 S or G2 M transitions in the cell cycle. In
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