This should definitely be built around, using creatures with evasion, double strike, and other good damage-enhancing abilities to mutate your commander onto
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In a lifegain-based deck, youll be able to trigger the Regent at least once before it dies, and more often than not 5-10 times
The upsides, like one additional on the count for Cranial Plating and friends, arent worth the risks
Minimum requirement to run Pokmon TCG Live on your PC OS: Microsoft Windows 7 or above MacOS 11 (Big Sur) or above Processor: Intel, AMD or Apple Silicon Processor RAM: Your PC must have at least 4GB of RAM
Storing a bunch of lands under it, then casting Obliterate, wiping the entire board and getting everything back that was exiled