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5-diyl)dibenzimidamide dihydrochloride
50892-23-4
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
and prostate cancer cells in vitro
Chemical Name: 4-((4-((((1R
MLN2238 - CAS# 1072833-77-2 Catalog No.:M6657-10 5-diyl)dibenzimidamide dihydrochlorideMLN2238, CAS No. 1072833 77 2, is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL2238 is also . the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(C) Bcl X(L) GEM model, only
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