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[Epub ahead of print] PubMed PMID: 27923910
56(16):6495-511
InChi: InChI=1S/C30H36N4O2
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Smiles: CC(C)(C)[C@H](NC(=O)COCCCCOC1C=CC(=CC=1)C1C=CC(=CC=1)N1C(=S)N(C(=O)C1(C)C)C1=CC(=C(C=C1)C#N)C(F)(F)F)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(=CC=1)C1SC=NC=1C
MLN4924 Hydrochloride - CAS# 1160295-21-5 Catalog No.:M10954-2 [Epub ahead of print] PubMedPevonedistat, also known as MLN 4924 and TAK 924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down regulated 8), an ubiquitin like (UBL) protein that modifies cellular targets in a pathway that is
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