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CAS Number: 1146963-51-0
Cancer: a twist in a hedgehog's tale
InChi: InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation
It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM
PR-619 - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 2645-32-1 268 CAS Number: 1146963-51-0PR 619, CAS No. 2645 32 1, is a cell permeable, non selective, reversible broad range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1 20 M. PR 619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose and time dependent manner (20 to 150 M, 0. 5 to 20 h) without direct impairment of proteasomal proteolysis. PR 619 treatment results in upregulation of both K48 and K63 linked polyUb chains. It induces
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