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Vismodegib (GDC-0449)
selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4 with IC50 of ~98 nM and 220 nM respectively
76(4):821-7
In H69 and H345 cells which have functional Met receptor
Rodriguez AL
CC-930 - CAS# 899805-25-5 Catalog No.:M6544-10 Vismodegib (GDC-0449)CC 930, also known as Tanzisertib, CAS No. 899805 25 5, is a potent, selective, and orally active JNK inhibitor with potential antifibrotic activity. CC 930 entered Phase I clinical trials. Tanzisertib may have potential use for prevention and treatment of dermal fibrosis. Selective inhibition of JNK by CC 930 exerted potent antifibrotic effects in vitro and in different models in vivo. JNK might thus be a novel molecular target for the treatment of
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