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(2011) Nature 480
Srivastava M
InChi: InChI=1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8
It has ~28-fold greater selectivity over UCH-L3 (ubiquitin C-terminal hydrolase L3)
It may potentially evade drug resistance in cancer cells
Nocodazole - Microtubule Inhibitor / CRISPR Editing Enhancer. CAS# 31430-18-9 60239 (2011) Nature 480Nocodazole, CAS No. 31430 18 9, is a potent microtubule inhibitor to inhibit mitosis. It disrupts microtubules by binding to tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Nocodazole arrests the cell cycle at G2 M phase and also prevents phosphorylation of the T cell antigen receptor and inhibits its