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Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules
Z433927330 is also a partial AQP3 inhibitor (IC50
CN1C2=CC=C(C=C2N=C1CCCC(O)=O)N(CCCl)CCCl
2817-2822 (2004)
InChiKey: VEXAKEBSBMAIOB-DHZHZOJOSA-N
THIQ rafenib D3) Chemogenetic Control of Protein AnchoringTHIQ is the first selective agonist of the melanocortin 4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1. 2 nM, EC50=2. 1 nM) and rMC4R (IC50=0. 6 nM, EC50=2. 9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants. Product
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