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Smiles: CC1=CC(O)=C(C=C1N=O)C(C)C
31-18-17(27)16(26)15(25)13(8-22)30-18)10-4-5-21(29
) to mice bearing 786-0 RCC xenografts is well tolerated
InChi: InChI=1S/C42H63O4P/c1-37(2
11-28-15-6-2-12(9-23)3-7-15)17(26)25-14-5-4-13(10-24)16(8-14)19(20
(R)-CR8 trihydrochloride Size:10mg solid Smiles: CC1=CC(O)=C(C=C1N=O)C(C)C(R) CR8 (CR8) trihydrochloride, a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 trihydrochloride inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R) CR8 trihydrochloride acts as a molecular glue degrader that
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