Tenapanor 1 (188-204) (TFA) PS372424 competes for binding of

PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM

Chemical Name: 6-fluoro-1H-indazol-3-ol

3-diylidene)bis(methaneylylidene))dibenzonitrile

Smiles: CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1

H3N/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45

Tenapanor 1 (188-204) (TFA) PS372424 competes for binding ofTenapanor is an inhibitor of the Na+ H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. Product information CAS Number: 1234423 95 0 Molecular Weight: 1145. 05 Formula: C50H66Cl4N8O10S2 Chemical Name: 3 {2 [2 (2 {3 [(4S) 6,8 dichloro 2 methyl 1,2,3,4 tetrahydroisoquinolin 4 yl]benzenesulfonamido}ethoxy)ethoxy]ethyl} 1 {4 [({2 [2 (2 {3 [(4S) 6,8 dichloro 2 methyl 1,2,3,4 tetrahydroisoquinolin 4