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InChiKey: ZULJGOSFKWFVRX-UHFFFAOYSA-N
Chemical Name: (2S)-2-amino-5-[(E)-N''-methylcarbamimidamido]pentanoic acid
7aS)-4-[(acetyloxy)methyl]-7-hydroxy-1
10 570 PMID: 25415586
3S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoic acid
Tivozanib (hydrate) Size:Contact [email protected] for quotation InChiKey: ZULJGOSFKWFVRX-UHFFFAOYSA-NTivozanib, also known as AV 951 and KRN 951, is an orally active, ATP competitive, small molecule, quinoline urea derivative. Tivozanib is a pan VEGFR tyrosine kinase inhibitor. In vitro: Tivozanib markedly inhibited the ligand induced phosphorylation of VEGFR1\2 and 3 with the IC50 value of 30 nM\6. 5 nM and 15 nM, respectively. Tivozanib also exihibited inhibitory effects on PDGFR and c Ki with the IC50 value of 1. 72 and 1. 63 nmol L, respectively.