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SNS-032 has antitumor effect
Compound 401 shows activity against mTOR (IC50=5
Formula: C22H21N3O2
CAS Number: 2070018-29-8
48 hours) leads to accumulation of cleaved (active) caspase-3
Cinobufagin en-d5 SNS-032 has antitumor effectCinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0. 1, 1, or 10 M after 24 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24 hr culture as well as caspase 3
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