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The coexpression of the LUBAC subunits in HEK293T cells increases the intracellular amounts of linear polyubiquitin
induces gp130 phosphorylation (S782) and deglycosylation
Using a combination of chemical
It displays >17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested
Smiles: COC1C=C(CCC2=CC(NC(=O)C3C=CC(=CC=3)N3C[C@H](C)N[C@H](C)C3)=NN2)C=C(C=1)OC
TPX-0131 - CAS# 2648641-36-3 yl Carvedilol The coexpression of the LUBACTPX 0131 is a potent, selective, CNS penetrant and orally active inhibitor of wild type ALK (IC50 of 1. 4 nM) and ALK resistant mutation, e. g. G1202R (IC50 of 0. 3 nM), L1196M (IC50 of 0. 3 nM). TPX 0131 has strong antitumor activities. Product information CAS Number: 2648641 36 3 Molecular Weight: 447. 41 Formula: C21H20F3N5O3 Chemical Name: (18S) 18 (difluoromethyl) 13 fluoro 7,7 dimethyl 9,20 dioxa 1,2,6,17,23 pentaazapentacyclo[19. 3. 1. 0,. 0,.