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CAS Number: 925701-88-8
MLN-9708 treatment increases the levels of pro-apoptotic proteins and down regulates the anti-apoptotic proteins that control MOMP
MX-1 and DLD-1 with ED75 from 4
InChi: InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3
CAS Number: 68099-86-5
TAK-715 odiamide hydrate CAS Number: 925701-88-8TAK 715 is a potent p38 MAPK inhibitor. which displays potent inhibitory activity (inhibition of p38alpha, IC50 = 7. 1 nM; LPS stimulated release of TNF alpha from THP 1, IC50 = 48 nM; LPS induced TNF alpha production in mice, 87. 6% inhibition at 10 mg kg, po) and no inhibitory activity for major CYPs, including CYP3A4. TAK 715 was selected as a clinical candidate and is now under clinical investigation for the treatment of RA. Product information
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