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shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 µM) and JAK2 (50 µM)
CC(C[N+](C)(C)C)OC(N)=O
CAS Number: 875337-44-3
Identification of ML204
90(3-4):205-11
3-Deazaneplanocin A Hydrochloride - CAS# 120964-45-6 (GX15-070) shows weaker inhibition of EGFR3 deazaneplanocin A, also known as DZNep, is a well known histone methyltransferase inhibitor, which disrupts polycomb repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma. DZNep is a promising therapeutic agent for ovarian cancer cells, with potential to inhibit proliferation, induce apoptosis and decrease migration. Product
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