Pay in 4 interest-free payments of $11.25 Learn more
Ships within 48 hours · Estimated delivery Aug 2 - Aug 7
It irreversibly binds to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions
PubMed PMID: 22713795
which inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM
Takizawa T
PIK-III acutely inhibits autophagy and de novo lipidation of LC3
(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 It irreversibly binds to a(Z) 4 Hydroxytamoxifen (also called 4 OH TAM), CAS No. 68047 06 3, was previously characterized as an Estrogen Receptor antagonist and now found to improve genome editing specificity in CRISPR mediated gene editing. It can activate intein linked inactive Cas9, reducing off target. Such system has ~25 fold higher specificity than wtCas9. (Z) 4 Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency