There are decks I have where I dont play Generous Gift or Stroke of Midnight because it gives my opponent a blocker decks like go-wide builds, or my Nahiri build that uses Living Weapon/For Mirrodin
Lorwyn Eclipsed Mechanics We're headed back to Lorwyn
Door to Destinies [Vampire deck]: This must be really good in commander tribal, where four drops are mid-game
split between creature / artifact / enchantment removal and countermagic 8 targeted removal
It also negates targeted removal and even some mass removal like All is Dust

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