Everybody loves a pupper, but WotC has to answer for its seeming Cat bias
Since infect puts -1/-1 counters on creatures it deals damage to, this allows Yawgmoth to act as removal so long as you have a sacrifice outlet
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Creatures with saddle can attack or block as normal even if they aren't saddled
Mana-deprivation-related: Similarly, if you have an effect that taps an opponent's mana sources, this is usually the time to use them
Not likely, Guard against counters and you'll be left with a commander that easily threatens lethal commander damage