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At doses of 10 to 40 mg/kg
1H3/b11-4+
Chemical Name: (2E)-2-(1
Bhattacharyya S
31)/t18-/m1/s1
AMG-548 dihydrochloride Size:2mg solid At doses of 10 toAMG 548 dihydrochloride, an orally active and selective p38 inhibitor (Ki=0. 5 nM), shows slightly selective over p38 (Ki=36 nM) and >1000 fold selective against p38 and p38. AMG 548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNF (IC50=3 nM). AMG 548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms and . Product information Molecular Weight: 534. 48 Formula:
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