Tyk2-IN-9 Catalog No.:M27281-C YKL-05-099 displays cell-based activities consistent

YKL-05-099 displays cell-based activities consistent with SIK inhibition

InChi: InChI=1S/C20H26N2S/c1-5-16-10-11-20-18(12-16)22(14-15(2)13-21(3)4)17-8-6-7-9-19(17)23-20/h6-12

7-dimethoxyquinazoline (PD 153035)

24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects up to 100 μM

7-trien-15-one

Tyk2-IN-9 Catalog No.:M27281-C YKL-05-099 displays cell-based activities consistentTyk2 IN 9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2 IN 9, example 19, is extracted from patent US2017240552A1. Product information CAS Number: 2127109 85 5 Molecular Weight: 383. 41 Formula: C20H17N9 Chemical Name: 3 (cyanomethyl) 3 {4 [6 (1 methyl 1H pyrazol 4 yl)pyrazolo[1,5 a]pyrazin 4 yl] 1H pyrazol 1 yl}cyclobutane 1 carbonitrile Smiles: