Cot inhibitor-1 Catalog No.:M11164-10 25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13

25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13

2-dimethyl-3-oxo-2H

Formula: C18H19NO3

InChi: InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7

It blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells

Cot inhibitor-1 Catalog No.:M11164-10 25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13Cot inhibitor 1 (compound 28) is a selective tumor progression loci 2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor 1 shows an inhibition of TNF alpha production in human whole blood with an IC50 of 5. 7 nM. Product information CAS Number: 915365 57 0 Molecular Weight: 553. 46 Formula: C27H27Cl2FN8 Chemical Name: 6 [({1 [2 (azepan 1 yl)ethyl] 1H 1,2,3 triazol 4 yl}methyl)amino] 8 chloro 4 [(3 chloro 4 fluorophenyl)amino]quinoline 3