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GSK3368715 (EPZ019997) produces a shift in arginine methylation states
28 µM) with DHA (GPR40 ligand) as a positive control (EC50=3
33)/t19-/m1/s1
3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%
structure-activity relationships
AZD4573 ugates 9 GSK3368715 (EPZ019997) produces a shiftAZD4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies. Product information CAS Number: 2057509 72 3 Molecular Weight: 429. 94 Formula: C22H28ClN5O2 Chemical Name: (1S,3R) N (5 chloro 4 {5,5 dimethyl 4H,5H,6H pyrrolo[1,2 b]pyrazol 3 yl}pyridin 2 yl) 3 acetamidocyclohexane 1 carboxamide Smiles:
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